I personally like to buy from Amazon, since they generally offer good prices, and have a great no-hassle return policy. All the GPS units below are on special Black Friday sale pricing all week, and are shipped directly from Amazon:

Update: Amazon has a special "Deal of the Day" for today only: Garmin nuvi 285WT for $129.99 (48% off)

Garmin nuvi 260W Read the Review List Price: $229.99 Amazon: $119.99 You Save: $110.00 (48%) In Stock	Garmin nuvi 265WT Read the Review List Price: $349.99 Amazon: $162.79 You Save: $187.20 (53%) In Stock	Garmin nuvi 765T Read the Review List Price: $499.99 Amazon: $209.99 You Save: $290.00 (58%) In Stock
Garmin nuvi 780 Read the Review List Price: $699.99 Amazon: $178.00 You Save: $521.99 (75%) In Stock	Garmin nuvi 785T Read the Review List Price: $549.99 Amazon: $249.99 You Save: $300.00 (55%) In Stock	Magellan RoadMate 1424 List Price: $149.99 Amazon: $109.99 You Save: $40.00 (27%) In Stock
Garmin nuvi 855 List Price: $499.99 Amazon: $199.99 You Save: $300.00 (60%) In Stock	Garmin Forerunner 305 w/ Heart Rate Monitor List Price: $299.99 Amazon: $139.99 You Save: $160.00 (53%) In Stock	Magellan Maestro 4700 Read the Review List Price: $299.99 Amazon: $179.99 You Save: $120.00 (40%) In Stock
Magellan RoadMate 1220 List Price: $159.99 Amazon: $89.99 You Save: $70.00 (44%) In Stock	Magellan RoadMate 1440 Read the Review List Price: $199.99 Amazon: $112.93 You Save: $87.06 (44%) In Stock	Magellan RoadMate 1470 List Price: $249.99 Amazon: $139.99 You Save: $110.00 (44%) In Stock
Magellan RoadMate 1700 List Price: $299.99 Amazon: $199.99 You Save: $100.00 (33%) In Stock	TomTom XL 330S (Factory Refurbished) List Price: $89.99 Amazon: $89.99 In Stock	DeLorme Earthmate PN-30 List Price: $299.95 Amazon: $179.99 You Save: $119.96 (40%) In Stock
DeLorme Earthmate PN-40 List Price: $399.95 Amazon: $229.99 You Save: $169.96 (42%) In Stock	Magellan Maestro 4250 Read the Review List Price: $299.00 Amazon: $99.99 You Save: $199.01 (67%) In Stock	Garmin nuvi 205 Read the Review List Price: $129.99 Amazon: $89.99 You Save: $40.00 (31%) In Stock
Garmin nuvi 255 List Price: $249.99 Amazon: $109.99 You Save: $140.00 (56%) In Stock	TomTom ONE 140 Read the Review List Price: $179.95 Amazon: $89.99 You Save: $89.96 (50%) In Stock	TomTom XL 340 List Price: $229.95 Amazon: $99.99 You Save: $129.96 (57%) In Stock
TomTom ONE 140-S Read the Review List Price: $199.95 Amazon: $99.96 You Save: $99.96 (50%) In Stock	Garmin nuvi 1300 List Price: $249.99 Amazon: $158.00 You Save: $91.99 (37%) In Stock	Garmin nuvi 885T Read the Review List Price: $599.99 Amazon: $299.00 You Save: $300.00 (50%) In Stock

I've looked through all the various Black Friday sales, and these appear to be the best prices offered on the following GPS units:

• Garmin Colorado 400T Handheld Mapping GPS - Abe's of Maine: $329
• Garmin 60CSx - Amazon: $248
• Garmin nuvi 1200 - Amazon: $129
• Garmin nuvi 1200 - Office Max: $119 (in-store only on Black Friday only)
• Garmin nuvi 1300 - Amazon: $157.81
• Garmin nuvi 1350 - Amazon: $183.06
• Garmin nuvi 465T - Amazon: $424.87
• Mio Moov M300 - Radio Shack: $79.99
• Mio Moov S501 - Radio Shack: $129.99
• DeLorme PN-20 Handheld - Walmart: $99

Some important free advice: All the GPS models I've listed above are good units that will serve you well. Unlike most of the useless stuff people buy during the holidays, a GPS will be a wonderful addition to your life and you'll quickly wonder how you survived without one. Prices are lower than ever, and this is a great time to buy your first GPS or replace an older model.

* Be cautious of ultra-cheap deals from brands you've never heard of. I recommend sticking with the major brands: Garmin, TomTom, Magellan, and buying from a reputable e-tailer or store with a good return policy. Also, be sure to read the GPSmagazine Buyer's Guide before making your purchase.